Furthermore, 14-3-3 proteins have chaperone activity which may play a role in neurodegenerative disease progression. Dysregulation of 14-3-3 protein expression has been observed in several cancers. Through these protein–protein interactions, 14-3-3 proteins participate in cell cycle regulation, gene expression control, apoptosis, signal transduction, and many other vital biological processes. They interact with numerous protein targets, including kinases, phosphatases, transmembrane receptors, and transcription factors. The name “14-3-3” was given because these proteins elute in the 14th fraction of bovine brain homogenate on the DEAE cellulose column and the 3.3 fraction in the subsequent starch gel electrophoresis. ![]() The 14-3-3 proteins are ubiquitously expressed in various tissues and mediate many cellular signaling pathways. Considering the critical roles of 14-3-3 proteins, there is an urgent need for investigating the involvement of 14-3-3 proteins in the phase separation process of their targets and the underling mechanisms. By modulating the conformation and valence of interactions and recruiting other molecules, we speculate that 14-3-3 proteins can efficiently regulate the functions of their targets in the context of LLPS. We further analyzed the phase separation behavior of representative 14-3-3 binders and discussed how 14-3-3 proteins may be involved. To reveal the potential involvement of 14-3-3 proteins in LLPS, in this review, we summarized the LLPS propensity of 14-3-3 binding partners and found that about one half of them may undergo LLPS spontaneously. To date, 14-3-3 proteins have not been reported to undergo LLPS alone or regulate LLPS of their binding partners. While extensive investigations have been performed on 14-3-3 proteins, its involvement in LLPS is overlooked. In the past ten years, LLPS has been observed for a variety of proteins and biological processes, indicating that LLPS plays a fundamental role in the formation of membraneless organelles and cellular condensates. The 14-3-3 binding motifs are often embedded in intrinsically disordered regions which are closely associated with liquid–liquid phase separation (LLPS). They interact with numerous protein targets and mediate many cellular signaling pathways. Color codes provide an indication for the conventionality of the chord, or the particular settings chosen.The 14-3-3 family proteins are vital scaffold proteins that ubiquitously expressed in various tissues. ![]() Any change is made in real time, and is immediately audible for the user. Chords are presented as rectangular boxes, with a vertical slider and two rotary knobs for changing chord functions, substituting chords, and adding tensions, respectively. melodies, bass lines, chords, loops, rhythmic patterns, etc.). Musical adaptation (resynthesis) builds meaningful musical context from various input data (e.g. ![]() It’s simple on the outside, yet sophisticated and intelligent inside.Ī very powerful harmonic analysis atomizes even very complex multi-track songs and detects their various musical elements and their correlations. It unleashes their creativity to make better music intuitively – without restrictions. Liquid Notes is the exact opposite to this trend: we take the complexity back to music making, without any complexity for the user behind it. Numbers are hard to get in DJing, but multiple sources talk about >10 million people using DJ software today. Thanks to the large amount of technology available today, automated mixing is becoming more worrying and used by a great many. Ibiza legend Tim Sheridan recently spoke out about ‘EDM killing the art of DJing’, in particular referring to the responsibility of ‘sync buttons’ and ‘laptop DJing’ creating today’s Plastic DJs.
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